Abstract：The mesoporous silica loaded with acetamiprid/F127 ( ( EO) 106 ( PO) 70 ( EO) 106) was prepared by instantaneous-liquid-crystal-template method. The structure of the samples were systematically characterized by Fourier transform infrared spectroscopy ( FTIR) , Differential scanning calorimeter ( DSC) , Scanning electron microscope ( SEM) , Transmission electron microscope ( TEM) and BrunauerEmmett-Teller ( BET) . The behavior of release of the mesoporous-silica were also investigated. The results showed that acetamiprid was successfully loaded on mesoporous silica and was present with an amorphous phase. They have IM-3 M's structure of and lamellar structures with a high degree of crystallinity in the horizontal direction. The results of N2 adsorption-desorption were showed a typical type Ⅳ-features and cage-like pore structure with a relatively uniform mesoporous channels, and the pore size distribution between 3 to 4 nm. The drug release curves of different drug-loaded mesoporous silica could be in line with by kinetic model of Korsmeyer-Peppas.
2018, Vol. 31 
