Abstract:In recent years, a new type gout with a high lethality has outbreak in gosling in China, which featured with urate deposition in joint and viscera, leading to huge economic loss. Several researches show that, a novel Goose Astrovirus (GoAstV) is the pathogen for this gout outbreak. In order to know about the epidemic and variation of GoAstV in Guangdong province, epidemiology of GoAstV in gosling in Guangdong was performed. The results show that the positive rate of GoAstV in gosling is 40%, which indicates that GoAstV is epidemic in gosling. The evolutionary analysis shows that GoAstV-DBN shares highest homology with AHAU2/2018, and no obvious variation was observed in GoAstV in Guangdong. However, Y36V and L540Q amino acid mutation in Cap protein occurred in GoAstV-DBN. This study provides a basis and reference for the prevention of GoAstV in Guangdong province.