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Abstract Circular RNA (circRNA) is a type of single-stranded, covalently closed-loop RNA produced by reverse splicing of initial transcription RNA. Because of the lack of 5′ cap and 3′ poly-A tail, circRNA is not easy to be degraded by RNA exonuclease or ribonuclease, and has higher stability than linear RNA. In this paper, the production mechanism, biological function and role of circRNA in animal reproduction were reviewed, and the research progress of circRNA in animal reproduction in recent years was summarized, aiming to provide some theoretical basis and new ideas for the research of circRNA in animals.
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2021, Vol. 34 
