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Abstract Polyamine-fipronil microcapsules(FIP@PDA) were prepared by in-situ polymerization using dopamine(DA) hydrochloride as a monomer and Fipronil(FIP) as the model drug. The multilayer FIP@PDA-n was prepared by multilayer cladding with FIP@PDA as the core. The structure and morphology of the sustained-release system were characterized by Transmission electron microscope(TEM), Energy Dispersive X-Ray Spectroscopy(EDX), Fourier transform infrared spectroscopy(FTIR), Differential scanning calorimeter(DSC). The adhesion and sustained-release properties of the system were discussed. The results showed that FIP @PDA-n has good adhesion and fipronil were existed in the form of crystal. Drug release was affected by the number of coating layers. The cumulative release rate was 85.6% when the coating was double-layer and 58.2% when it was covered with 6 layers. Its drug release could be described by the First-Order kinetic model, and controlled by the diffusion of concentration gradients.
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Received: 18 September 2020
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2019, Vol. 32 
